A case report of vaccine-induced immune thrombocytopenia and thrombosis syndrome after Ad26.COV2.S vaccine (Janssen/Johnson & Johnson)

France, Castan et al, January 2022, Therapie Summary On August 2, 2021, ten days after receiving a dose of Ad26.COV2.S vaccine (Janssen/Johnson & Johnson), a 57-years-old man was admitted for left hemiplegia. The rest of clinical examination was unremarkable. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing by nasopharyngeal swab was … Continue reading A case report of vaccine-induced immune thrombocytopenia and thrombosis syndrome after Ad26.COV2.S vaccine (Janssen/Johnson & Johnson)

Thrombocytopenia with and without Thrombosis Following COVID-19 Vaccination

Canada, 5 November 2021, Ge et al, Thrombosis Summary Among 9 patients with thrombocytopenia included in this cohort, the median age was 55 years (range 24 to 73), and 5 patients (56%) were female. Seven patients received AZ and 2 had Pfizer vaccines. All events occurred after the first dose of COVID-19 vaccine with a … Continue reading Thrombocytopenia with and without Thrombosis Following COVID-19 Vaccination

COVID-19 vaccine-associated cerebral venous thrombosis in Germany: a descriptive study

Germany, 4 May 2021, Schultz et al, Annals of Neurology Summary We designed web-based questionnaire, which was e-mailed to all Departments of Neurology of University and non-university hospitals in Germany on April 6, 2021. Data collection was closed at midnight on April 14, 2021. We asked to report cases of cerebral sinus-venous thrombosis, cerebral venous … Continue reading COVID-19 vaccine-associated cerebral venous thrombosis in Germany: a descriptive study

Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score

21 September 2021, Hwang et al, European Heart Journal Summary PubMed, Scopus, Embase, and Web of Science databases were searched and the resulting articles were reviewed. A total of 6 case series and 13 case reports (64 patients) of TTS after ChAdOx1 nCoV-19 vaccination were included. We performed a pooled analysis and developed a novel … Continue reading Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score

COVID-19 Vaccine-Associated Thrombosis With Thrombocytopenia Syndrome (TTS): A Systematic Review and Post Hoc Analysis

Pakistan, 7 September 2021, Hafeez et al, Clinical and Applied Thrombosis/Hemostasis Summary We utilized the World Health Organization’s criteria for a confirmed and probable case of TTS following COVID-19 vaccination and conducted a systematic review and posthoc analysis using the PRISMA 2020 statement. Of the 175 studies identified, a total of 25 studies with 69 … Continue reading COVID-19 Vaccine-Associated Thrombosis With Thrombocytopenia Syndrome (TTS): A Systematic Review and Post Hoc Analysis

Imaging findings in a patient with suspected vaccine induced immune thrombotic thrombocytopenia

U.K, 21 September 2021, Kadam et al, British Institute of Radiology Summary We present the case of a 55-year-old patient with post-vaccination complication. The patient was vaccinated with ChAdOx1 nCov-19 Vaccine and 2 weeks later presented with headache, confusion and abdominal pain for 1 week duration. Clinical examination demonstrated reduced Glasgow Coma Scale (GCS), reduced … Continue reading Imaging findings in a patient with suspected vaccine induced immune thrombotic thrombocytopenia

Successful Treatment of Vaccine-Induced Immune Thrombotic Thrombocytopenia in a 26 Year-Old Female Patient

Germany, 6 October 2021, Kemper et al, Acta Haematologica Summary We report the case of a 26-year-old female patient, who developed bilateral deep vein thrombosis in the lower legs and severe thrombocytopenia after ChAdOx2 nCov-19 vaccination. After initial anticoagulationtherapy regimens including fondaparinux, apixaban, and danaparoid failed, the patient was successfully treated with high-dose intravenous immunoglobulins … Continue reading Successful Treatment of Vaccine-Induced Immune Thrombotic Thrombocytopenia in a 26 Year-Old Female Patient

Endovascular treatment for vaccine-induced cerebral venous sinus thrombosis and thrombocytopenia following ChAdOx1 nCoV-19 vaccination: a report of three cases

U.K, 2 November 2021, Cleaver et al, Journal of Neurointerventional Surgery Summary Patient records from 1 January 2021 to 20 July 2021 identified three patients who underwent endovascular treatment for CVST in the context of VITT. All were female and the median age was 52 years. The location of the CVST was highly variable. Two-thirds … Continue reading Endovascular treatment for vaccine-induced cerebral venous sinus thrombosis and thrombocytopenia following ChAdOx1 nCoV-19 vaccination: a report of three cases

Massive cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia

Italy, 1 November 2021, Bonato et al, Haematolgica Summary We describe an Italian case of severe VITT-related cerebral venous thrombosis (CVT) and bi-hemispheric hemorrhage, which was treated with argatroban, intravenous immunoglobulin (IVIG) and corticosteroids. A previously healthy 26-year-old female presented to the emergency department 14 days after the first injection of ChAdOx1 nCoV-19 vaccine with … Continue reading Massive cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia

Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series

Norway, 30 July 2021, Weidman et al, Fronteirs in Neurology Summary During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was the rapid and severe progression of disease in spite of maximum treatment efforts, resulting in fatal outcome in … Continue reading Vaccine Induced Immune Thrombotic Thrombocytopenia Causing a Severe Form of Cerebral Venous Thrombosis With High Fatality Rate: A Case Series

Using Nonheparin Anticoagulant to Treat a Near-Fatal Case With Multiple Venous Thrombotic Lesions During ChAdOx1 nCoV-19 Vaccination-Related Vaccine-Induced Immune Thrombotic Thrombocytopenia

France, 1 September 2021, Bersinger et al, Critical Care Medicine Summary Few days after the first dose of the ChAdOx1 nCoV-19 vaccine, a 21-year-old woman experienced massive thrombosis in the deep and superficial cerebral veins together with seizures, neurologic focal deficit, and thrombocytopenia. In the neurointensive care unit, her condition worsened despite early decompressive craniectomy. … Continue reading Using Nonheparin Anticoagulant to Treat a Near-Fatal Case With Multiple Venous Thrombotic Lesions During ChAdOx1 nCoV-19 Vaccination-Related Vaccine-Induced Immune Thrombotic Thrombocytopenia

Vaccine-Induced Immune Thrombotic Thrombocytopenia with Disseminated Intravascular Coagulation and Death following the ChAdOx1 nCoV-19 Vaccine

Saudi Arabia, 30 September 2021, Aladdin et al, Journal of Stroke and Cerebrovascular Diseases Summary We report a fatal case of vaccine-induced immune thrombotic thrombocytopenia (VITT) in a 36 year old lady, after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. CT-venogram demonstrated extensive dural venous sinus thrombosis of the superior sagittal sinus and … Continue reading Vaccine-Induced Immune Thrombotic Thrombocytopenia with Disseminated Intravascular Coagulation and Death following the ChAdOx1 nCoV-19 Vaccine

Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia

28 September 2021, van Kammen et al, JAMA Neurology Summary This cohort study used data from an international registry of consecutive patients with CVST within 28 days of SARS-CoV-2 vaccination included between March 29 and June 18, 2021, from 81 hospitals in 19 countries. For reference, data from patients with CVST between 2015 and 2018 … Continue reading Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia

Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination

9 September 2021, Munckhof et al, European Journal of Neurology Summary The EudraVigilance database of the European Medicines Agency was used to identify cases of CVST with concomitant thrombocytopenia occurring within 28 days of SARS-CoV-2 vaccination. Vaccines were grouped based on vaccine type (adenoviral or mRNA). Cases with CVST onset until 28 March were compared … Continue reading Declining mortality of cerebral venous sinus thrombosis with thrombocytopenia after SARS-CoV-2 vaccination

Cerebral venous thrombosis post BNT162b2 mRNA SARS‐CoV‐2 vaccination: A black swan event

Singapore, 26 June 2021, Fan et al, American Journal of Haematology Summary We present three cases of CVT post BNT162b2 mRNA SARS‐CoV‐2 vaccination. Patient 1: A healthy 54‐year‐old Chinese male with well controlled hyperlipidaemia, developed severe headache and vomiting 24 h after his second dose of BNT162b2 mRNA vaccine, and acute left hemiparesis 2 days later. A … Continue reading Cerebral venous thrombosis post BNT162b2 mRNA SARS‐CoV‐2 vaccination: A black swan event

Vaccine-induced thrombosis and thrombocytopenia with bilateral adrenal haemorrhage

U.K, 8 July 2021, Taylor et al, Clinical Endocrinology Summary A 38-year-old male with no significant medical history and no family history of clotting disorders attended the emergency unit with sudden onset of severe abdominal pain and vomiting. He had received his first dose of the ChAdOx1 vaccine 8 days prior. Observations were normal and … Continue reading Vaccine-induced thrombosis and thrombocytopenia with bilateral adrenal haemorrhage

Pulmonary embolism, transient ischaemic attack and thrombocytopenia after the Johnson & Johnson COVID-19 vaccine

U.S, 25 June 2021, Malik et al, BMJ Case Reports Summary We present the case of a 43-year-old woman with a history of dyslipidaemia, depression, gastro-oesophageal reflux disease and obesity presenting with dyspnoea, headache and light headedness of 3 days’ duration. Ten days prior, she had received the J&J COVID-19 vaccine. She was found to have … Continue reading Pulmonary embolism, transient ischaemic attack and thrombocytopenia after the Johnson & Johnson COVID-19 vaccine

Diagnosis and Management of Cerebral Venous Sinus Thrombosis With Vaccine-Induced Immune Thrombotic Thrombocytopenia

July 2021, Stroke Summary Recent reports from the Centers of Disease Control and the US Food and Drug Administration identified 6 cases of CVST associated with thrombocytopenia in US patients who had received the Ad26.COV2.S (Janssen) coronavirus disease 2019 (COVID-19) vaccine. Similar thromboembolic events were reported in Europe following ChAdOx1 nCoV-19 (AstraZeneca) vaccination. Both the … Continue reading Diagnosis and Management of Cerebral Venous Sinus Thrombosis With Vaccine-Induced Immune Thrombotic Thrombocytopenia