A case report of vaccine-induced immune thrombocytopenia and thrombosis syndrome after Ad26.COV2.S vaccine (Janssen/Johnson & Johnson)

France, Castan et al, January 2022, Therapie Summary On August 2, 2021, ten days after receiving a dose of Ad26.COV2.S vaccine (Janssen/Johnson & Johnson), a 57-years-old man was admitted for left hemiplegia. The rest of clinical examination was unremarkable. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing by nasopharyngeal swab was … Continue reading A case report of vaccine-induced immune thrombocytopenia and thrombosis syndrome after Ad26.COV2.S vaccine (Janssen/Johnson & Johnson)

Organ Donation From a Brain Dead Donor With Vaccine-induced Immune Thrombotic Thrombocytopenia After Ad26.COV2.S: The Risk of Organ Microthrombi

Germany, Uzen et al, November 2021, Transplantation Summary A 50-y-old female developed VITT with severe thrombocytopenia and thrombosis of the cerebral arteries and venous sinuses 12 d after the Ad26.COV2.S (Johnson & Johnson) vaccine. A  computed tomography (CT) scan showed extensive ischemia of both cerebral hemispheres and incipient entrapment of the brain stem. CT angiography revealed occlusion … Continue reading Organ Donation From a Brain Dead Donor With Vaccine-induced Immune Thrombotic Thrombocytopenia After Ad26.COV2.S: The Risk of Organ Microthrombi

Central Retinal Vein Occlusion Following BNT162b2 (Pfizer-BioNTech) COVID-19 Messenger RNA Vaccine

U.S, 1 December 2021, Shah et al, Retinal Cases & Brief Reports Summary A 27-year-old female was diagnosed with central retinal vein occlusion (CRVO) a few days after her first dose of the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine. Detailed elicitation of her history and a full hypercoagulable workup did not reveal any primary risk factors that … Continue reading Central Retinal Vein Occlusion Following BNT162b2 (Pfizer-BioNTech) COVID-19 Messenger RNA Vaccine

CDC has updated its recommendations for COVID-19 vaccines with a preference for people to receive an mRNA COVID-19 vaccine (Pfizer-BioNTech and Moderna).

Updated Dec. 20, 2021 Summary Thrombosis with thrombocytopenia syndrome (TTS) after Johnson & Johnson’s Janssen (J&J/Janssen) COVID-19 vaccination CDC and FDA identified 57 confirmed reports of people who got the J&J/Janssen COVID-19 vaccine and later developed TTS.CDC has also identified nine deaths that have been caused by or were directly attributed to TTS following J&J/Janssen … Continue reading CDC has updated its recommendations for COVID-19 vaccines with a preference for people to receive an mRNA COVID-19 vaccine (Pfizer-BioNTech and Moderna).

Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults

U.S, 6 December 2021, Truong et al, Circulation Summary We report on 139 adolescents and young adults with 140 episodes of suspected myocarditis (49 confirmed, 91 probable) at 26 centers. Most patients were male (N=126, 90.6%) and White (N=92, 66.2%); 29 (20.9%) were Hispanic; and median age was 15.8 years (range 12.1-20.3, IQR 14.5-17.0). Suspected … Continue reading Clinically Suspected Myocarditis Temporally Related to COVID-19 Vaccination in Adolescents and Young Adults

Acute-onset polyradiculoneuropathy after SARS-CoV2 vaccine in the West and North Midlands, United Kingdom

U.K, 16 November 2021, Loo et al, Muscle and Nerve Summary We retrospectively reviewed records of all persons presenting with acute-onset polyradiculoneuropathy from January 1, 2021, to June 30, 2021, admitted to two Neuroscience centers, of the West and North Midlands, United Kingdom. We compared subjects with previous SARS-CoV2 vaccine exposure with a local cohort … Continue reading Acute-onset polyradiculoneuropathy after SARS-CoV2 vaccine in the West and North Midlands, United Kingdom

Toxic Epidermal Necrolysis Post COVID-19 Vaccination – First Reported Case

Saudi Arabia, 5 August 2021, Bakir et al, Cureus Summary A 49-year-old woman with no previous medical history presented to the emergency room with a history of fever and skin eruption. She has received COVID-19 Pfizer (BNT162b1) vaccine with a dose of 0.3 mL given intramuscularly one week before the development of her symptoms. The … Continue reading Toxic Epidermal Necrolysis Post COVID-19 Vaccination – First Reported Case

MODERNA VACCINE PULMONARY EMBOLISM: ASSOCIATION VS COINCIDENCE

U.S, 11 October 2021, Saxby et al, Chest Summary A 55-year-old healthy, physically active male of Ashkenazi Jewish descent presents with multiple bilateral segmental and sub-segmental pulmonary embolisms. Twenty-four hours prior to onset of symptoms, the two-vaccine series of Moderna was completed. The patient was both COVID-19 PCR and COVID-19 IgG antibody negative, but positive … Continue reading MODERNA VACCINE PULMONARY EMBOLISM: ASSOCIATION VS COINCIDENCE

Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination

Japan, 16 November 2021, Yagi et al, Neurological Sciences Summary Here, we report a case of CVST with prolonged mild headache after mRNA-based COVID-19 vaccination. A man in his 50 s without remarkable medical history visited our department complaining of 1-week headache, which started 26–30 h after his second dose of tozinameran (Comirnaty® from Pfizer–BioNtech). He was … Continue reading Cerebral venous sinus thrombosis after mRNA-based COVID-19 vaccination

Thrombocytopenia with and without Thrombosis Following COVID-19 Vaccination

Canada, 5 November 2021, Ge et al, Thrombosis Summary Among 9 patients with thrombocytopenia included in this cohort, the median age was 55 years (range 24 to 73), and 5 patients (56%) were female. Seven patients received AZ and 2 had Pfizer vaccines. All events occurred after the first dose of COVID-19 vaccine with a … Continue reading Thrombocytopenia with and without Thrombosis Following COVID-19 Vaccination

Unusual Site of Deep Vein Thrombosis After mRNA Coronavirus Disease-2019 (COVID-19) Vaccination

Japan, Hasegawa et al, Circulation Journal Summary Venous thromboembolism (VTE) complications reportedly occur in unusual sites after ChAdOx2 nCoV-19 (AstraZeneca) vaccination, but few reports on the development of VTE after mRNA COVID-19 vaccination (Pfizer-BioNTech) have been published. A 72-year-old Japanese woman presented with persistent left arm claudication after receiving the mRNA COVID-19 vaccine. Both doses … Continue reading Unusual Site of Deep Vein Thrombosis After mRNA Coronavirus Disease-2019 (COVID-19) Vaccination

Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine

U.S, 6 April 2021, Helms et al, Journal of Blood Medicine Summary We report a 74-year-old man who developed refractory thrombocytopenia within one day of receiving the Moderna SARS-CoV-2 vaccine. Several hours after vaccination, he developed significant epistaxis and cutaneous purpura. Severe thrombocytopenia was documented the following day, and he developed extremity weakness and encephalopathy … Continue reading Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine

Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination

U.S 3 November 2021, Kahn et al, Critical Care Explorations Summary A 20-year-old male college student in good health developed tinnitus and hematuria shortly (2 hours) after vaccination and progressed swiftly to a syndrome of: systemic inflammation; acute kidney injury requiring hemodialysis; acute, bilateral, complete sensorineural hearing loss; radiographic evidence of acute multifocal ischemic strokes; … Continue reading Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination

Occurrence of acute infarct-like myocarditis following COVID-19 vaccination: just an accidental co-incidence or rather vaccination-associated autoimmune myocarditis?

Germany, 31 July 2021, Chamling et al, Clinical Research in Cardiology Summary We would like to present the findings of three different patients that presented to our hospital until mid of June 2021 and showed unusual serious adverse cardiovascular events of infarct-like myocarditis (in the absence of CAD), possibly linked to preceding COVID-19 vaccination. CMR … Continue reading Occurrence of acute infarct-like myocarditis following COVID-19 vaccination: just an accidental co-incidence or rather vaccination-associated autoimmune myocarditis?

Perimyocarditis in Adolescents After Pfizer BioNTech COVID-19 Vaccine

U.S, 28 July 2021, Tano et al, Journal of the Pediatric Infectious Diseases Society Summary We describe clinical characteristics of 8 adolescents who presented over the course of 36 days to Nicklaus Children’s Hospital with perimyocarditis within 4 days of receiving a dose of BNT162b2 vaccine. Twelve lead electrocardiogram from patient 2, demonstrating sinus rhythm … Continue reading Perimyocarditis in Adolescents After Pfizer BioNTech COVID-19 Vaccine

Acute Myocarditis Following the Administration of the Second BNT162b2 COVID-19 Vaccine Dose

Saudi Arabia, Miqdad et al, 18 October 2021, Cureus Summary This is an 18-year-old male with no significant past medical history, presented to the emergency department complaining of central crushing chest pain four days following the second dose of the BNT162b2 COVID-19 vaccine. The pain was aggravated by respiration with no radiation or other associated … Continue reading Acute Myocarditis Following the Administration of the Second BNT162b2 COVID-19 Vaccine Dose

Acute myocarditis associated with anti-COVID-19 vaccination

Israel, 28 June 2021, Nevet et al, Clinical and Experimental Vaccine Research Summary Three previously healthy men, 20, 29, and 24 years old, presented to the emergency department due to acute fever and chest pain appearing 2 days after receiving the second dose of BNT162b2. No abnormal heart sounds or evidence of heart failure were … Continue reading Acute myocarditis associated with anti-COVID-19 vaccination

Myopericarditis After the Pfizer Messenger Ribonucleic Acid Coronavirus Disease Vaccine in Adolescents

U.S, 3 July 2021, Schauer et al, The Journal of Pedriatrics Summary We describe 13 patients aged 12-17 years who presented with chest pain within 1 week after their second dose of the Pfizer vaccine and were found to have elevated serum troponin levels and evidence of myopericarditis. All patients underwent CMR within 1 week … Continue reading Myopericarditis After the Pfizer Messenger Ribonucleic Acid Coronavirus Disease Vaccine in Adolescents

COVID-19 vaccine-associated cerebral venous thrombosis in Germany: a descriptive study

Germany, 4 May 2021, Schultz et al, Annals of Neurology Summary We designed web-based questionnaire, which was e-mailed to all Departments of Neurology of University and non-university hospitals in Germany on April 6, 2021. Data collection was closed at midnight on April 14, 2021. We asked to report cases of cerebral sinus-venous thrombosis, cerebral venous … Continue reading COVID-19 vaccine-associated cerebral venous thrombosis in Germany: a descriptive study

Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score

21 September 2021, Hwang et al, European Heart Journal Summary PubMed, Scopus, Embase, and Web of Science databases were searched and the resulting articles were reviewed. A total of 6 case series and 13 case reports (64 patients) of TTS after ChAdOx1 nCoV-19 vaccination were included. We performed a pooled analysis and developed a novel … Continue reading Predictors of mortality in thrombotic thrombocytopenia after adenoviral COVID-19 vaccination: the FAPIC score