A case series of acute pericarditis following COVID-19 vaccination in the context of recent reports from Europe and the United States

Greece, 5 October 2021, Lazaros et al, Vaccine


We report nine events of acute pericarditis (AP) in eight patients following COVID-19 vaccination with BNT162b2 (6/9), AZD1222 (2/9) and mRNA-1273. Five events occurred after the first vaccine dose and four after the second. The mean age in this cohort was 65.8 ± 10.2 years and the men/women ratio 3/5. All events resolved without sequelae; two events were complicated by cardiac tamponade requiring emergent pericardial decompression. Hospitalization was required in four cases.

In all cases PCR for SARS-CoV 2 and serum h-TnI were negative. Similarly, no alternative etiology for acute pericarditis was found during work up. Details on comorbidities, chronic medical treatment, treatment at baseline and medical treatment. * NV < 14 in females and < 34 in males. **All patients received colchicine 0.5 twice daily. &Last follow-up by the end of June. Events #5 and #6 refer to the same patient reporting clinical data relevant to the first attack (#5) and first recurrence (#6). CRP = C reactive protein, NV = normal values, ECG = electrocardiogram, COVID-19 = coronavirus disease 2019, Hs TnI = high-sensitivity troponin I, NSF = Non-specific findings, MPdn = methylprednisolone

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