Temporal association between the COVID-19 Ad26.COV2.S vaccine and acute myocarditis: A case report and literature review

U.S 9 August 2021, Sulemankhil et al, Cardiovascular Revascularization Medicine


Out of 38 articles, 23 case reports and case series were selected for further analysis. These articles included 81 patients with 77 males who were primarily under the age of 30. Onset of myocarditis was noted in 71 individuals following their second mRNA COVID-19 vaccine; nine individuals following their first mRNA COVID-19 vaccine, of which six had a prior COVID-19 infection; and one individual had myocarditis following administration of the Janssen Ad26.COV2.S vaccine. Whereas 31.8% of all individuals vaccinated were below the age of 40 years old, they constituted 80.7% of all myocarditis cases. Further, in individuals below the age of 29 years old, the observed cases of myocarditis were in excess of the expected cases.

Fig. 3
Cardiac magnetic resonance of a four-chamber, long-axis T2-weighted image demonstrating small focal edema (arrow) in the anterolateral wall of the left ventricle.

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