Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT)

Austria, 18 April 2021, Thaler et al, Journal of Thrombosis and Haemostasis

Summary

Here, we report a case of a 62-year-old woman who had received this vaccine and developed VIPIT. She visited the emergency ward because of petechiae and hematomas. In the laboratory work-up, thrombocytopenia, low fibrinogen, elevated D-dimer, and positivity in the platelet factor 4/heparin-enzyme-immunoassay were present. Signs and symptoms of thrombosis were absent. Upon immediate therapy with non-heparin anticoagulation, high-dose IVIG, and prednisolone, laboratory parameters steadily improved and the patient was discharged from hospital without thrombotic complications. We conclude that early initiation of VIPIT treatment results in a swift response without thrombotic complications.

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Time course of platelet count (red), fibrinogen concentration (yellow), and D-dimer (blue) during treatment of vaccine-induced prothrombotic immune thrombocytopenia

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