Immune thrombocytopenia in a 22-year-old post Covid-19 vaccine

U.S, 19 January 2021, American Journal of Haematology


A 22-year-old healthy male with no medication use received the Pfizer-BioNTech BNT16B2b2 mRNA vaccine through his work as an emergency department employee. On day three, post-vaccination, he experienced widespread petechiae (Figure 1) and gum bleeding, which prompted his presentation. He was current on his vaccines, including yearly influenza, with no history of adverse reactions. He denied respiratory and gastrointestinal complaints or a history of infection. He had no personal or family history of bleeding or autoimmune disease. Laboratory tests revealed severe thrombocytopenia with a platelet count of 2 × 109/L. Two months prior to receiving the vaccine, the patient was evaluated at an outpatient clinic for upper respiratory symptoms. His PCR assay returned negative for SARS-CoV-2, and complete blood count was unremarkable with a normal platelet count of 145 × 109/L (reference range, 140–400 × 109/L). 


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