Perspectives on vaccine induced thrombotic thrombocytopenia

Israel, 18 May 2021, Journal of Autoimmunity

Summary

A sum of 41 ChAdOx1 nCov-19 induced catastrophic thrombotic thrombocytopenia cases are documented in peered reviewed journals, 39 of which in 3 articles published by ‘The New England Journal of Medicine’. All the examined individuals were in a medically stable condition at the time of vaccination and the vast majority had no preexisting prothrombotic condition in their medical history.

“Mechanism of action of the ChAdOx1 nCov-19 vaccine includes a modified version of a chimpanzee adenovirus, known as ChAdOx1, that has the ability to insert artificial DNA into human cells. The objective is to generate synthesis of SARS-CoV-2 spike protein by the cells of the inoculated, which will lead to a rigorous bystander activation of immune cells. The existence of molecular mimicry between the vaccine-induced proteins of SARS-CoV-2 and human components might give rise to potential side effects by leading to the production of pathological autoantibodies, resulting in vaccine-induced autoimmunity…”

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