Early Outcomes of Bivalirudin Therapy for Thrombotic Thrombocytopenia and Cerebral Venous Sinus Thrombosis After Ad26.COV2.S Vaccination

U.S, October 2021, Annals of Emergency Medicine

Summary

A 40-year-old Caucasian woman was found to have thrombocytopenia, cerebral venous sinus thrombosis, and pulmonary embolism following vaccination for COVID-19 with Ad26.COV2.S. She exhibited a steady rise in platelet count: 20×109/L at hospital day 0, 115×109/L at discharge on hospital day 6, and 182×109/L on outpatient follow-up on day 9.

Figure thumbnail gr1
Computed tomography venogram showing cerebral venous thrombosis of the sigmoid sinus extending into the jugular vein. The arrow shows the lack of enhancement of the left sigmoid sinus.

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