Fatal vaccine‑induced immune thrombotic thrombocytopenia (VITT) post Ad26.COV2.S (J&J): first documented case outside US

1 October 2021, Infection

Summary

A 37 year old woman without any medical history presented with deep vein thrombosis and thrombocytopenia at day 10 after vaccine injection. Twelve days post Ad26.COV2.S vaccination, the patient was admitted at our hospital for neurological deterioration and right hemiplegia. Medical imaging using MRI showed thrombosis of the major anterior part of the sagittal superior sinus with bilateral intraparenchymal hemorrhagic complications. Despite immediate treatment with intravenous immunoglobulin, dexamethasone, danaparoid and attempted neurosurgery the patient demised.

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