Vaccine-induced immune thrombotic thrombocytopenia

November 11, 2021, Lancet Haematology

Summary

In this Viewpoint, we discuss the epidemiology, pathophysiology, and optimal diagnostic and therapeutic management of VITT.

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Timeline of the development of adenovirus-based coronavirus vaccines and first recognition of vaccine-induced immune thrombotic thrombocytopenia
On August 12, 2021, the full report from the first 294 UK cases was published.9 EMA=European Medicines Agency. MHRA=Medicines and Healthcare Products Regulatory Agency. VITT=vaccine-induced immune thrombotic thrombocytopenia.

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Proposed pathophysiology of vaccine-induced immune thrombotic thrombocytopenia
PF4=platelet factor 4.

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Overview of the diagnostic investigation of VITT
Functional assays might involve a functional heparin-induced platelet activation assay, a serotonin-release assay, or a flow-based platelet activation assay. FEU=fibrinogen-equivalent units. VITT=vaccine-induced immune thrombotic thrombocytopenia.

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